Rheumatoid Arthritis: Early Diagnosis and Treatment, 4E
Reviews the importance of early treatment of RA, appropriate testing and imaging to be employed, and outcomes data on the treatment of early and established RA. Clinical evaluation is presented, including lab findings, joint scoring, diagnostic criteria, and radiographic outcomes. The rationale and data supporting early treatment of RA are reviewed. The appropriate use of disease-modifying antirheumatic drugs (DMARDS) as monotherapy and in combination is presented.
The use of TNF inhibitors in the treatment of RA is reviewed in detail, including pivotal clinical trials data. Separate chapters are dedicated to interleukin-1 inhibitors, B-cell targeted therapies, T-cell pathway blockers, interleukin-6 inhibitors, and kinase inhibitors. The clinical efficacy, dosing, indications for use, mechanisms of action, side effects, and safety of all these biologic therapies are reviewed in detail. In addition, the appendix contains a how-to guide for setting up an early arthritis clinic.
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