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Premier Edition of Mechanisms of Action of Antiepileptic Drugs by H. Steve White, PhD and Jong M. Rho, MD Published

03-26-2010

Professional Communications, Inc, is pleased to announce the publication of the Premier Edition of Mechanisms of Action of Antiepileptic Drugs by H. Steve White, PhD and Jong M. Rho, MD. 

This book reviews what is known and unknown about how each of these drugs classes exerts its anticonvulsant effect and how this information may be utilized in guiding selection of appropriate drugs and combination of drugs. The knowledge provided in the book may also help explain why some classes of AEDs worsen certain seizure types and thus should be avoided. Study of the underlying molecular mechanisms, coupled with insights on the underlying pathology of epilepsy, should improve the ability to develop future treatments that may be more efficacious and better tolerated. 
 
The mechanisms of action of each of the available antiepileptic drug classes are reviewed, including Voltage-Dependent Sodium Channels, GABAergic Modulators, Glutamate Receptors, T-Type Calcium Channels and HCN Channels, Presynaptic Synaptic Vesicle 2A and Calcium Channel α2δ Proteins, Potassium Channels, and Multiple or Unknown Mechanisms.
 
Numerous 4-color illustrations are utilized to convey key concepts.
 
H. Steve White, PhD is Professor and Director of the Anticonvulsant Development Program at the University of Utah. Jong M. Rho, MD is Senior Staff Scientist at the Barrow Neurological Institute.
  
2010 166 pages, 4-color, ISBN: 978-932610-66-6   $24.95

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